Moduretic is used for treating fluid retention (edema) and high blood pressure. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

Moduretic is a diuretic (water pill) and is a combination of a potassium-sparing diuretic (amiloride) and a thiazide diuretic (hydrochlorothiazide). It works by making the kidneys eliminate sodium (salt) and water from the body, which helps to lower blood pressure. The amiloride component helps minimize potassium loss.

Most important: Moduretic may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Moduretic with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Moduretic may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel “normal.” Tell your doctor if you develop any new symptoms.

Moduretic may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Moduretic. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Tell your doctor or dentist that you take Moduretic before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients – Moduretic may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Lab tests, including liver function, kidney function, lung function, blood pressure, and fasting blood glucose, may be performed while you use Moduretic. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Moduretic should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Moduretic while you are pregnant. It is not known if Moduretic is found in breast milk. Do not breast-feed while taking Moduretic.